ChloroquineV1, Main, Exploration, bibRecord, 002A44

Effects of Chloroquine Treatment on Antioxidant Enzymes in Rat Liver and Kidney

Identifieur interne : 002A44 ( Main/Exploration ); précédent : 002A43; suivant : 002A45

Effects of Chloroquine Treatment on Antioxidant Enzymes in Rat Liver and Kidney

Auteurs : Tapiwanashe Magwere [Zimbabwe] ; Yogeshkumar S. Naik [Zimbabwe] ; Julia A. Hasler [Zimbabwe]

Source :

Free Radical Biology and Medicine [ 0891-5849 ] ; 1997.

RBID : ISTEX:4ACC4E64288B02D07D4795D34506912790727F93

English descriptors

Abstract

Abstract: The effect of chloroquine (CHQ) administration on antioxidant enzymes in rat liver and kidney was studied. Male Sprague–Dawley rats were administered 20 mg/kg CHQ once a week for 4 weeks (chronic treatment) or a single dose at 10 or 20 mg/kg (acute treatment). Antioxidant enzyme activities were determined in cytosolic fractions of liver and kidney, whereas reduced glutathione (GSH) and malondialdehyde (MDA) were determined in tissue samples. Results indicate minimal effects of acute CHQ treatment, whereas chronic treatment with CHQ differentially affected antioxidant enzymes in the two organs. Superoxide dismutase activity was increased nearly twofold, while activities of selenium glutathione peroxidase (GPX), catalase, and NAD (P) H: quinone oxidoreductase were decreased in livers of CHQ-treated rats compared to controls. No significant effects of CHQ on glutathione reductase, GSH, and MDA levels were seen in the liver. Fewer effects of CHQ were observed in the kidney where a decrease in GPX activity and an increase in MDA levels was seen. Lowering of antioxidant enzymes activities in the liver by CHQ could render the organ more susceptible to subsequent oxidative stress; while increased MDA production after CHQ treatment in the kidney indicate that the organ is being subjected to oxidative stress. This could have implications for prolonged chloroquine intake.Copyright © 1996 Elsevier Science Inc.

Url:

https://api.istex.fr/ark:/67375/6H6-16Z1MWLV-2/fulltext.pdf

DOI: 10.1016/S0891-5849(96)00285-7

Affiliations:

Zimbabwe

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000873
to stream Istex, to step Curation: 000873
to stream Istex, to step Checkpoint: 001834
to stream Main, to step Merge: 002A96
to stream Main, to step Curation: 002A44

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of Chloroquine Treatment on Antioxidant Enzymes in Rat Liver and Kidney</title>
<author><name sortKey="Magwere, Tapiwanashe" sort="Magwere, Tapiwanashe" uniqKey="Magwere T" first="Tapiwanashe" last="Magwere">Tapiwanashe Magwere</name>
</author>
<author><name sortKey="Naik, Yogeshkumar S" sort="Naik, Yogeshkumar S" uniqKey="Naik Y" first="Yogeshkumar S" last="Naik">Yogeshkumar S. Naik</name>
</author>
<author><name sortKey="Hasler, Julia A" sort="Hasler, Julia A" uniqKey="Hasler J" first="Julia A" last="Hasler">Julia A. Hasler</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:4ACC4E64288B02D07D4795D34506912790727F93</idno>
<date when="1996" year="1996">1996</date>
<idno type="doi">10.1016/S0891-5849(96)00285-7</idno>
<idno type="url">https://api.istex.fr/ark:/67375/6H6-16Z1MWLV-2/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000873</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000873</idno>
<idno type="wicri:Area/Istex/Curation">000873</idno>
<idno type="wicri:Area/Istex/Checkpoint">001834</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001834</idno>
<idno type="wicri:doubleKey">0891-5849:1996:Magwere T:effects:of:chloroquine</idno>
<idno type="wicri:Area/Main/Merge">002A96</idno>
<idno type="wicri:Area/Main/Curation">002A44</idno>
<idno type="wicri:Area/Main/Exploration">002A44</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effects of Chloroquine Treatment on Antioxidant Enzymes in Rat Liver and Kidney</title>
<author><name sortKey="Magwere, Tapiwanashe" sort="Magwere, Tapiwanashe" uniqKey="Magwere T" first="Tapiwanashe" last="Magwere">Tapiwanashe Magwere</name>
<affiliation wicri:level="1"><country xml:lang="fr">Zimbabwe</country>
<wicri:regionArea>Department of Biochemistry, University of Zimbabwe, Mount Pleasant, Harare</wicri:regionArea>
<wicri:noRegion>Harare</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Naik, Yogeshkumar S" sort="Naik, Yogeshkumar S" uniqKey="Naik Y" first="Yogeshkumar S" last="Naik">Yogeshkumar S. Naik</name>
<affiliation wicri:level="1"><country xml:lang="fr">Zimbabwe</country>
<wicri:regionArea>Department of Biochemistry, University of Zimbabwe, Mount Pleasant, Harare</wicri:regionArea>
<wicri:noRegion>Harare</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hasler, Julia A" sort="Hasler, Julia A" uniqKey="Hasler J" first="Julia A" last="Hasler">Julia A. Hasler</name>
<affiliation wicri:level="1"><country xml:lang="fr">Zimbabwe</country>
<wicri:regionArea>Department of Biochemistry, University of Zimbabwe, Mount Pleasant, Harare</wicri:regionArea>
<wicri:noRegion>Harare</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Free Radical Biology and Medicine</title>
<title level="j" type="abbrev">FRB</title>
<idno type="ISSN">0891-5849</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1997">1997</date>
<biblScope unit="volume">22</biblScope>
<biblScope unit="issue">1–2</biblScope>
<biblScope unit="page" from="321">321</biblScope>
<biblScope unit="page" to="327">327</biblScope>
</imprint>
<idno type="ISSN">0891-5849</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0891-5849</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antioxidant enzymes</term>
<term>Chloroquine</term>
<term>Free radicals</term>
<term>Kidney</term>
<term>Liver</term>
<term>Oxidative stress</term>
<term>Rats</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Antimalarial</term>
<term>Antimalarial drugs</term>
<term>Antioxidant</term>
<term>Antioxidant enzyme activity</term>
<term>Antioxidant enzymes</term>
<term>Antioxidant status</term>
<term>Assay</term>
<term>Assay mixtures</term>
<term>Biochem</term>
<term>Biol</term>
<term>Boca raton</term>
<term>Chloroquine</term>
<term>Chloroquine treatment</term>
<term>Chronic chloroquine treatment</term>
<term>Chronic treatment</term>
<term>Cytosolic</term>
<term>Cytosolic fractions</term>
<term>Electron donor</term>
<term>Elsevier science</term>
<term>Endurance training</term>
<term>Enzyme</term>
<term>Enzyme activities</term>
<term>Fewer effects</term>
<term>Free radic</term>
<term>Glutathione</term>
<term>Glutathione peroxidase</term>
<term>Glutathione reductase</term>
<term>Hydrogen peroxide</term>
<term>Kidney</term>
<term>Lipid</term>
<term>Lipid peroxidation</term>
<term>Malondialdehyde levels</term>
<term>Methods enzymol</term>
<term>Open column control</term>
<term>Oxidative</term>
<term>Oxidative stress</term>
<term>Peroxidation</term>
<term>Plasmodium falciparum</term>
<term>Protein turnover</term>
<term>Quinone oxidoreductase</term>
<term>Rule column</term>
<term>Single dose</term>
<term>Solid column</term>
<term>Superoxide</term>
<term>Superoxide dismutase</term>
<term>Superoxide dismutases</term>
<term>Zimbabwe</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: The effect of chloroquine (CHQ) administration on antioxidant enzymes in rat liver and kidney was studied. Male Sprague–Dawley rats were administered 20 mg/kg CHQ once a week for 4 weeks (chronic treatment) or a single dose at 10 or 20 mg/kg (acute treatment). Antioxidant enzyme activities were determined in cytosolic fractions of liver and kidney, whereas reduced glutathione (GSH) and malondialdehyde (MDA) were determined in tissue samples. Results indicate minimal effects of acute CHQ treatment, whereas chronic treatment with CHQ differentially affected antioxidant enzymes in the two organs. Superoxide dismutase activity was increased nearly twofold, while activities of selenium glutathione peroxidase (GPX), catalase, and NAD (P) H: quinone oxidoreductase were decreased in livers of CHQ-treated rats compared to controls. No significant effects of CHQ on glutathione reductase, GSH, and MDA levels were seen in the liver. Fewer effects of CHQ were observed in the kidney where a decrease in GPX activity and an increase in MDA levels was seen. Lowering of antioxidant enzymes activities in the liver by CHQ could render the organ more susceptible to subsequent oxidative stress; while increased MDA production after CHQ treatment in the kidney indicate that the organ is being subjected to oxidative stress. This could have implications for prolonged chloroquine intake.Copyright © 1996 Elsevier Science Inc.</div>
</front>
</TEI>
<affiliations><list><country><li>Zimbabwe</li>
</country>
</list>
<tree><country name="Zimbabwe"><noRegion><name sortKey="Magwere, Tapiwanashe" sort="Magwere, Tapiwanashe" uniqKey="Magwere T" first="Tapiwanashe" last="Magwere">Tapiwanashe Magwere</name>
</noRegion>
<name sortKey="Hasler, Julia A" sort="Hasler, Julia A" uniqKey="Hasler J" first="Julia A" last="Hasler">Julia A. Hasler</name>
<name sortKey="Naik, Yogeshkumar S" sort="Naik, Yogeshkumar S" uniqKey="Naik Y" first="Yogeshkumar S" last="Naik">Yogeshkumar S. Naik</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002A44 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002A44 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:4ACC4E64288B02D07D4795D34506912790727F93
   |texte=   Effects of Chloroquine Treatment on Antioxidant Enzymes in Rat Liver and Kidney
}}

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Chloroquine

Effects of Chloroquine Treatment on Antioxidant Enzymes in Rat Liver and Kidney

Effects of Chloroquine Treatment on Antioxidant Enzymes in Rat Liver and Kidney

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri